Chandra Sekhar Pemmasani was born on 7 March 1976[6] at Burripalem, Guntur District in present-day Andhra Pradesh in an agricultural family to Pemmasani Sambasiva Rao and his wife Suvarchala.[7] He has a brother named Ravi Shankar Pemmasani. Although he was born in Burripalem, he spent some time in his childhood in Narasaraopet because of his father's hotel business.[8] He completed his 10th class in 1991 and his intermediate in 1993. With aspirations to become a doctor, he secured 27th rank in the EAMCET in 1993–94 and obtained a seat at Osmania Medical College in Hyderabad.[9]